You may have some other issues with your body position and bike setup. You mentioned you tent to lower the nose of your seat down a bit. I know what you mean there! Gotta protect the down under. But lowering it too much means you are putting more weight on the front of your bike and your wrists.
I will highly recommend getting a fitting done. I got mine and it recommended me the proper settings but I found the seat position they told me to use was too low. But it did help me with the forward/back and angle of the seat I should have been using.
Before I was less experienced I bought the Ergon grips because I had soreness on the palm of my hands. They would get numb from riding. Everyone would tell me it was just that I was not used to the position. I tried different gloves with gels and nothing fealt as good as the Ergon grips. However, when I started to do a bit more technical trails, I found that the Ergon grips made me loose a bit of the grip on my handle bars. When I reach for my brake I use my index and middle fingers. That leaves my ring and pinky as well as my thumb on the other side. Well that was okay but the Ergon grip is wider toward my pinky and ring fingers so those two fingers alone were not enoug grip when I was braking. It was GREAT for resting my palms but just not enough grip. Things got even uglier when I was braking AND using my thumb to shift down as we often do as we are slowing down. That left me completely expossed to no grip but my pinky and ring finger.
I switched to Oudry and have been on those ever since. I still do the "grip of death" as I decent step downhills so my hand still get sore. But if I relax my shoulders, move back my seat as well as use level angel, it helps my palms. I will use my Ergon grips on the 50 mile endurance races since there is little technical sections and is more about lasting 5-6 hrs on the bike. I must mention that I cut my handle bars about 1 1/2 inch on each side to give me more confidence through tight tree sections. That may have been the reason my Ergon grips were too close to my brakes and shifters. Again, I might experiement with them a bit more. So if you use the Ergons make sure you leave at least 1/2 from the inside tip to the shifters and brake handles. That way you will shift your hands inwards when you need to shift/brake and give you more grip for the pinky and ring figers. When not shifting/braking you can relax your hands outwars doward the palm rest of the Ergon grip where there is little to no grip. Also experiment with the different angles the palm rest is to be used. If too high of an angle and you are riding in a relax mode, it doesn't take a big bump for your hand to kind of slide forward away from the grip.
Do a fitting if you can but if not, experiment with several grips, grip angles, and seat positions until you are confortable and have less numbness.