I am glad you posted. I did see your shout.
This is probably more complicated than we could get in that function.
There are so many variables. And I am sure that my friends here will point out some things that I miss.
Your inseam, and then how long are your arms are probably the most important.
Have you ridden before, and what do you anticipate will be the kind of riding you do.
Being that you are a bigger guy, you definitely don't need to worry about buying the lightest bike on the market. You want to get something that is very durable. You are what is called a "Clydesdale" (so am I) buy a bike designed for you.
What is your budget? Do you think that you will have money available later to make upgrades?
These are questions that you need to consider. You need to ride some bikes, go to more than one bike shop, and be open. Some shops might try and upsell you while others may be more concerned about your needs.